The placement of a harmonizer pedal in a guitar effects chain can vary depending on the desired sound and the other pedals being used.
In general, harmonizer pedals are typically placed towards the end of the effects chain, after time-based effects like delay and reverb, and before distortion or overdrive pedals.
This allows the harmonizer to process a clean and natural-sounding guitar signal and to respond accurately to the player’s playing dynamics.
However, the exact placement can be adjusted to taste, and some players may prefer to place the harmonizer before other effects for a more experimental sound.